Inhibitors of Copi and Copii Do Not Block PEX3-Mediated Peroxisome Synthesis
نویسندگان
چکیده
منابع مشابه
Inhibitors of Copi and Copii Do Not Block PEX3-Mediated Peroxisome Synthesis
In humans, defects in peroxisome biogenesis are the cause of lethal diseases typified by Zellweger syndrome. Here, we show that inactivating mutations in human PEX3 cause Zellweger syndrome, abrogate peroxisome membrane synthesis, and result in reduced abundance of peroxisomal membrane proteins (PMPs) and/or mislocalization of PMPs to the mitochondria. Previous studies have suggested that PEX3 ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2000
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.149.7.1345